Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.
OBJECTIVE: Effect of fingolimod in multiple sclerosis (MS) is thought to involve the prevention of lymphocyte egress from lymphoid tissues, thereby reducing autoaggressive lymphocyte infiltration into the central nervous system across blood-brain barrier (BBB).However, brain microvascular endothelial cells (BMECs) represent a possible additional ta